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X-WR-CALNAME:Irvine Center for Addiction Neuroscience (ICAN)
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X-WR-CALDESC:Events for Irvine Center for Addiction Neuroscience (ICAN)
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DTSTART;TZID=America/Los_Angeles:20241118T080000
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DTSTAMP:20260418T002614
CREATED:20240923T231656Z
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UID:442-1731916800-1731952800@ican.uci.edu
SUMMARY:ICAN Symposium
DESCRIPTION:New Tricks for Old Drugs? Psychedelics Through the Lens of Science\, Treatment\, and Policy\n \n \nYou are invited! Join us for the annual ICAN Symposium! \nDate: Monday\, November 18\, 2024\nTime: 8:00am – 6:00pm\nLocation: CNLM Herklotz Conference Room \nRegister here.\nView the agenda here.\nFor any questions related to the ICAN Symposium\, please submit inquiries directly to nbb@uci.edu.
URL:https://ican.uci.edu/event/ican-symposium/
LOCATION:Herklotz Conference Room\, Center for the Neurobiology of Learning and Memory\, 300 Qureshey Research Lab
CATEGORIES:Symposium
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230601T110000
DTEND;TZID=America/Los_Angeles:20230601T120000
DTSTAMP:20260418T002614
CREATED:20230530T180937Z
LAST-MODIFIED:20230530T180937Z
UID:375-1685617200-1685620800@ican.uci.edu
SUMMARY:Adolescent cannabinoid exposure: effects on dopamine system development and cocaine-motivated behavior
DESCRIPTION:Featuring:\nNatalie E. Zlebnik\, PhD\nDivision of Biomedical Sciences\,\nUniversity of California\,\nRiverside School of Medicine\nHybrid Event\nThis seminar will be live-streamed via Zoom and In-Person.\nIn-Person:\nHerklotz Conference Room\nCenter for the Neurobiology of Learning and Memory\n300 Qureshey Research Lab\n\nZoom: https://uci.zoom.us/j/91353149742#success \nAbstract:\nCannabis is the most commonly abused illicit drug among adolescents\, and excessive use in this population is associated with the development of psychiatric conditions\, including drug addiction. Adolescence is a critical period for the refinement and organization of neuronal connectivity\, especially within the mesocorticolimbic dopamine circuity. In particular\, dysregulation of the guidance cue receptor\, Dcc\, in ventral tegmental area (VTA) dopamine neurons disrupts spatiotemporal targeting of dopamine axons to the nucleus accumbens (NAc) and the medial prefrontal cortex (mPFC). We have previously demonstrated that exposure to amphetamine in early adolescence disrupts the development of dopamine circuitry development\, leading to alterations in cognitive processing and drug seeking in adulthood. Here\, we examine whether exposure to the synthetic cannabinoid 1 receptor (CB1R) agonist WIN-55\,212-2 (WIN) in early adolescence regulates Dcc mRNA expression in the VTA and induces alterations in drug-motivated behaviors and in dopamine function in adulthood. Preliminary findings demonstrate that adolescent exposure to WIN downregulates the Dcc receptor in the VTA and disrupts organization of mesocorticolimbic dopamine circuitry. Additionally\, WIN-treated mice display aberrant self-administration of cocaine in the absence of other behavioral impairments. Ongoing experiments will elucidate functional changes in cocaine-evoked phasic dopamine release in the NAc and mPFC. Overall\, these findings support that repeated exposure to a CB1R agonist in adolescence impacts mesocorticolimbic dopamine system maturation and may have important implications for dopamine-mediated learning and psychostimulant-motivated behavior later in life. \nBio:\nNatalie Zlebnik\, PhD\, is an Assistant Professor in the Division of Biomedical Sciences in the School of Medicine. She earned her doctorate in Neuroscience from the University of Minnesota\, and her postdoctoral fellowship was completed at the University of Maryland School of Medicine\, where her investigations focused on the role of the endocannabinoid system in normal reward-motivated behaviors and its therapeutic role in disorders of reward seeking. Her independent research program examines how drugs of abuse exploit neural mechanisms of motivated behavior to promote relapse and facilitate the transition to drug addiction. The goal is to identify molecular and circuit-level targets for the development of novel therapeutics to reduce drug craving and minimize the propensity to relapse.
URL:https://ican.uci.edu/event/adolescent-cannabinoid-exposure-effects-on-dopamine-system-development-and-cocaine-motivated-behavior/
LOCATION:Herklotz Conference Room\, Center for the Neurobiology of Learning and Memory\, 300 Qureshey Research Lab
ATTACH;FMTTYPE=image/png:https://ican.uci.edu/wp-content/uploads/sites/48/2023/05/Natalie-Zlebnik.png
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230524T110000
DTEND;TZID=America/Los_Angeles:20230524T110000
DTSTAMP:20260418T002614
CREATED:20230511T175517Z
LAST-MODIFIED:20230511T180949Z
UID:360-1684926000-1684926000@ican.uci.edu
SUMMARY:Accumbens microglia are sex-specifically altered by nicotine use and critically regulate nicotine seeking and glutamatergic plasticity
DESCRIPTION:Featuring:\n\nCassandra D. Gipson-Reichardt\, Ph.D.\nAssociate Professor\nPharmacology and Nutritional Sciences\, College of Medicine\nUniversity of Kentucky\nHybrid Event\nThis seminar will be live-streamed via Zoom and In-Person.\nIn-Person:\nHerklotz Conference Room\nCenter for the Neurobiology of Learning and Memory\n300 Qureshey Research Lab\n\nZoom: https://neurobiology.uci.edu/event/ican-seminar-series-dr-tom-hnasko/ \nAbstract:\nNicotine use remains a substantial burden to public health. Neuroimmune mechanisms within the nucleus accumbens core (NAcore) are involved in nicotine-motivated behaviors\, and initiated nicotine seeking induces rapid\, transient plasticity (t-SP) in NAcore medium spiny neurons (MSNs). We have previously found increased pro-inflammatory cytokine expression and markers of microglial reactivity within the NAcore following chronic nicotine self-administration (SA) and during nicotine seeking\, and that reductions in NAcore neuroimmune signaling are necessary for pharmacotherapeutics to reduce nicotine seeking behavior. Microglia are brain immune cells\, and play a critical role in regulating neuronal activity and synaptic plasticity. Here we show that NAcore neuroimmune signaling is driven by nicotine seeking and consumption in a sex-specific fashion\, whereby males and females display unique microglia morphological changes. Learn more\nLEARN MORE
URL:https://ican.uci.edu/event/accumbens-microglia-are-sex-specifically-altered-by-nicotine-use-and-critically-regulate-nicotine-seeking-and-glutamatergic-plasticity/
LOCATION:Herklotz Conference Room\, Center for the Neurobiology of Learning and Memory\, 300 Qureshey Research Lab
ATTACH;FMTTYPE=image/png:https://ican.uci.edu/wp-content/uploads/sites/48/2023/05/Cassandra-D.-Gipson-Reichardt.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230504T110000
DTEND;TZID=America/Los_Angeles:20230504T120000
DTSTAMP:20260418T002614
CREATED:20230426T154206Z
LAST-MODIFIED:20230426T154600Z
UID:355-1683198000-1683201600@ican.uci.edu
SUMMARY:Heterogeneous VTA cell types reinforce behaviors through diverse mechanisms
DESCRIPTION:Featuring: Tom Hnasko\, PhD\nDepartment of Neurosciences\nUniversity of California\, San Diego\nHybrid Event\nThis seminar will be live-streamed via Zoom and In-Person.\nIn-Person:\nHerklotz Conference Room\nCenter for the Neurobiology of Learning and Memory\n300 Qureshey Research Lab\n\nZoom: https://neurobiology.uci.edu/event/ican-seminar-series-dr-tom-hnasko/ \nAbstract:\nThe ventral tegmental area (VTA) is famous for its dopamine neurons. However\, non-dopamine neurons are abundant in VTA\, including GABA neurons\, glutamate neurons\, and neurons that release more than one of these recycling neurotransmitters. This seminar will focus on several recent non-canonical findings on how VTA cell types are regulated by afferents\, connected to distal targets\, and impact behavioral reinforcement. Including examples of how co-release of neurotransmitters from VTA neurons can drive divergent physiological and behavioral responses. The work suggests that VTA neurons reinforce behaviors by dopamine as well as by dopamine-independent mechanisms.\nLEARN MORE
URL:https://ican.uci.edu/event/355/
LOCATION:Herklotz Conference Room\, Center for the Neurobiology of Learning and Memory\, 300 Qureshey Research Lab
ATTACH;FMTTYPE=image/png:https://ican.uci.edu/wp-content/uploads/sites/48/2023/04/Tom-Hnasko.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230420T110000
DTEND;TZID=America/Los_Angeles:20230420T120000
DTSTAMP:20260418T002614
CREATED:20230414T225309Z
LAST-MODIFIED:20230414T225546Z
UID:347-1681988400-1681992000@ican.uci.edu
SUMMARY:Functional consequences of psychotropic drug exposure early in development
DESCRIPTION:Featuring: Arturo Zavala\, PhD\nDepartment of Psychology\nCalifornia State University\,\nLong Beach\n  \nHybrid Event\nThis seminar will be live-streamed via Zoom and In-Person.\nIn-Person:\nHerklotz Conference Room\nCenter for the Neurobiology of Learning and Memory\n300 Qureshey Research Lab\nZoom: https://uci.zoom.us/meeting/register/tJUucuqpqjItHtbaNGUCZJoZCND2WGkGcRHW \nAbstract:\nAttention Deficit Hyperactivity Disorder (ADHD) and depression are the most common diagnoses in children and adolescents\, and the use of medications to treat these conditions has increased dramatically over the past three decades. However\, little research has examined the functional consequences of early and extended use of these medications. Preclinical studies demonstrate that early exposure to methylphenidate (Ritalin) and fluoxetine (Prozac) enhances the abuse potential of cocaine. I will present data from animal studies that show the effects of early exposure to methylphenidate and ketamine\, a recently approved antidepressant\, on the rewarding effects of nicotine and alcohol in adolescent male and female rats. The findings from these studies have significant clinical implications for the use of psychotropic drugs in children and adolescents. LEARN MORE \nDr. Arturo Zavala is a Professor in the Department of Psychology at California State University\, Long Beach. He received his Ph.D. in Behavioral Neuroscience from Arizona State University. Dr. Zavala’s research program focuses on the functional consequences of early exposure to psychoactive drugs and later susceptibility to drug abuse\, as well as the role of serotonin and glucagon-like peptide 1 in modulating the effects of drugs of abuse. His laboratory combines neurochemical\, molecular\, and pharmacological approaches with animal behavioral models to understand the neural basis of addiction. Dr. Zavala is also Co-Director of the Building Infrastructure Leading to Diversity (BUILD) program\, which aims to increase the number of underrepresented students entering biomedical and health-related research careers. LEARN MORE
URL:https://ican.uci.edu/event/functional-consequences-of-psychotropic-drug-exposure-early-in-development/
LOCATION:Herklotz Conference Room\, Center for the Neurobiology of Learning and Memory\, 300 Qureshey Research Lab
ATTACH;FMTTYPE=image/png:https://ican.uci.edu/wp-content/uploads/sites/48/2023/04/Arturo-Zavala-Presentation-169.png
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