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DTSTART;TZID=America/Los_Angeles:20230524T110000
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CREATED:20230511T175517Z
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UID:360-1684926000-1684926000@ican.uci.edu
SUMMARY:Accumbens microglia are sex-specifically altered by nicotine use and critically regulate nicotine seeking and glutamatergic plasticity
DESCRIPTION:Featuring:\n\nCassandra D. Gipson-Reichardt\, Ph.D.\nAssociate Professor\nPharmacology and Nutritional Sciences\, College of Medicine\nUniversity of Kentucky\nHybrid Event\nThis seminar will be live-streamed via Zoom and In-Person.\nIn-Person:\nHerklotz Conference Room\nCenter for the Neurobiology of Learning and Memory\n300 Qureshey Research Lab\n\nZoom: https://neurobiology.uci.edu/event/ican-seminar-series-dr-tom-hnasko/ \nAbstract:\nNicotine use remains a substantial burden to public health. Neuroimmune mechanisms within the nucleus accumbens core (NAcore) are involved in nicotine-motivated behaviors\, and initiated nicotine seeking induces rapid\, transient plasticity (t-SP) in NAcore medium spiny neurons (MSNs). We have previously found increased pro-inflammatory cytokine expression and markers of microglial reactivity within the NAcore following chronic nicotine self-administration (SA) and during nicotine seeking\, and that reductions in NAcore neuroimmune signaling are necessary for pharmacotherapeutics to reduce nicotine seeking behavior. Microglia are brain immune cells\, and play a critical role in regulating neuronal activity and synaptic plasticity. Here we show that NAcore neuroimmune signaling is driven by nicotine seeking and consumption in a sex-specific fashion\, whereby males and females display unique microglia morphological changes. Learn more\nLEARN MORE
URL:https://ican.uci.edu/event/accumbens-microglia-are-sex-specifically-altered-by-nicotine-use-and-critically-regulate-nicotine-seeking-and-glutamatergic-plasticity/
LOCATION:Herklotz Conference Room\, Center for the Neurobiology of Learning and Memory\, 300 Qureshey Research Lab
ATTACH;FMTTYPE=image/png:https://ican.uci.edu/wp-content/uploads/sites/48/2023/05/Cassandra-D.-Gipson-Reichardt.png
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